Synthesis, Characterization, and Biological Activity of Some New Amino Acid Derivatives Containing Selenium
Dhafir M. Husain Al-Mudhaffar, Adil A. Abdul Hasan

Abstract
New derivatives of some amino acids are synthesized by two steps. Firstly, by reaction of 3,5- dinitrobenzoyl chloride in equivalent molal ratio with potassium selenide, under argon atmospher, affording 3,5- dinitrobenzoyl isoselonocyanate (A). Then by adding immediately equivalent molal ratio of selected amino acids, namely; alanine, or glycine, to (A), give amino acid derivatives [3, 5-dinitrobenzoylamino-selenomethyl] Amino Acid (1 & 2). The new derivatives have been characterized by CHNS, IR, 1HNMR, 13CNMR. Compounds (1&2) have antibacterial activity against Staphylococcus aureus (NCTC6571) and Escherichia coli(NCTC5933).

Full Text: PDF