International Journal of Applied Science and Technology

ISSN 2221-0997 (Print), 2221-1004 (Online) 10.30845/ijast

Synthesis, Characterization of some gabapentin derivatives by Green Chemistry
Dhafir M. Husain Al-Mudhaffar, Nahid H. Rishag

Two new gabapentin derivatives were synthesized without solvent as green chemistry, by mixing gabapentin with sebacoylchioride in (2:1) molal ratio to give derivative (1). The second derivative(2)was synthesized by mixing one mole of benzoyl chloride with one mole of gabapentin without solvent. These derivatives(1) and (2)which act as ligands, were characterized by FT-IR, CHN, 1HNMR, 13CNMR measurements and thermal analysis. Complexes of gabapentin derivatives were prepared by adding MNO3. 3H2O, where M = Cu(II) , to gabapentin derivatives (1) in 2:1molal ratio and to derivative (2) in 1: 2 molal ratio of Cu(II) to the derivative (2). The complexes(3)and(4)have been characterized by FT-IR, CHN and thermal analysis.

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