Some Biochemical and Haematological Studies on the Methanolic Extract of Anthocleista Grandiflora Stem Bark
Odeghe Othuke B; Uwakwe A, A; Monago C.C

Abstract
This research was designed to access the interaction of Anthocleista grandiflora plant and chloroquine in mice induced with Plasmodium berghei with the aim of ascertaining the significance of such interaction in the treatment of malaria infection. A total of 89 mice were used for this study and were divided into six groups. Group 1 uninfected and untreated, Group 2 infected and treated with normal saline, Group 3 infected and treated with 300mg/kg b.wt extract, group 4 infected and treated with 500mg/kg b.wt extract, group 5 infected and treated with 700mg/kg b.wt extract and group 6 infected and treated with chloroquine (5mg/kg b.wt). The infected extract treated animals had significant (P<0.05) difference in PCV, Hb, WBC and platelet count from day 3 to day 14 when compared with the control. The elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and urea in the malaria rats were significantly (p<0.05) decreased.

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