Endothelial Nitric Oxide Function and Tubular Injury in Premature Infants
Huseynova Saadat, Akhundova Afag, Panakhova Nushaba, Hasanov Safikhan, Ali-zade Samaya

Abstract
The aim of this work was to determine the association between renal endothelial activation and tubular epithelial injury in low-birth-weight (LBW) and in very-low-birth-weight (VLBW) infants with hypoxic-ischemic encephalopathy (HIE). Urine samples from all of the infants were assessed for kidney injury molecule-1 (KIM-1) antigen and nitric oxide (NO) at their 1st and 7th days of life. The mean urine KIM-1 concentration was higher (1.5±0.4 ng/ml) in LBW infants compared with VLBW infants (0.8±0.4 ng/ml) and tended to decline in both groups of infants. In LBW infants, urine NO levels did not change, and the decline of NO was noted in the VLBW infants, decreasing from 418.4±84.54 µM/L to 261.2±20.2 µM/L. We observed the decease of KIM-1 concentration in a background of decreased nitric oxide metabolites , which may indicate low endothelium activation in response to ischemia-reperfusion and confirm the low probability of epithelial injury in VLBW infants.

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