Piper Guineense: A Possible Alternative Treatment for Multidrug Resistant EHEC
Emmanuel Adedayo Omonigbehin, Mope A. Deji-Agboola, Abimbola Rashidat Ezeh, Stella I. Smith, Moses Bamidele, Toun Wuraola Fesobi, Fowora Muinah Adenike, Akindele Samuel Kayode, Afolabi Oluwadun

Abstract
The susceptibility of sixteen (16) Enterohaemorrhagic Escherichia coli 0157: H7 isolates to conventional antibiotics and extracts of P. guineense was compared using agar diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was determined using broth dilution and agar diffusion methods respectively. The result of the susceptibility test showed that majority of the EHEC isolates were resistant to 63.64% of the antibiotics used, showing multidrug resistance. The antibacterial assay of P. guineense revealed inhibition against all the isolates (100%) with MIC (200mg/ml) and MBC (400mg/ml).

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