The Effectiveness of Hot Water and Aqueous-Methanol Extractions of Malaysian Swietenia Macrophylla King Seeds and Endocarps Combined on Diabetic Rats
Hanan Kumar G, Nur Hayati J M, N D Salih, R M Noah, Khairul Nizam M I, Muhammad Rohani J

Abstract
Practically, it’s thought by the traditional use of Swietenia macrophylla in Malaysia that it has a rational means for the treatment of diabetic patients, but with regard to alternative medicine, the ethno medicinal literature does not mention any adverse effect or reaction associated with Swietenia macrophylla seeds. This study has designed to evaluate the hypoglycemic effectiveness exhibited by the combination of seeds and endocarps extraction performed using water as solvent and compares it with an aqueous-methanol solvent extraction in vivo. We found that aqueous-methanol extract is active for alkaloids, flavonoids, cardiac glycosides, reducing sugar, saponins, tannins and terpenoids and it is also more efficient than the hot water extract in improving altered biological parameters impacted by hyperglycemia. Therefore, the aqueous-methanol appears ideal for extracting the necessary potent hypoglycemic compounds of the plant parts studied.

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