Preparation and Antibacterial Activity of Low Molecular Weight Quaternized Chitosan Gelatin Film with Iodine
Tang Yang, Sai Mingze, Xu Ningning, Ding Derun

Abstract
The chitosan was degraded to the low molecular weight chitosan (CTS') by oxidation, and the low molecular weight quaternized chitosan (QCTS') was prepared by CTS' with 3-chloro-2-hydroxypropyl three methyl ammonium chloride (CTA). The stable complex (QCTS'-I₂) was obtained using QCTS' and iodine, and the complex was mainly composed of uniform nanoparticles with the diameter of about 1000nm. The CTS-[QCTS'-I₂]-PVP gelatin film was prepared by QCTS' and chitosan with polyvinylpyrrolidone (PVP). The scanning electron microscopy (SEM) showed that the complex uniformly distributed on gelatin films. Approximately 6.5% of iodine was released in about 45mins in the phosphate buffer (pH 7.4). The antibacterial ring diameter of CTS-[QCTS'-I₂]-PVP gelatin film for E. coli and S. aureus is greater than 15 mm.

Full Text: PDF