Article Information
Original Research Article | Open Access | Peer Reviewed
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The Multifaceted Roles of PP2A-B56 in Tumor Progression
Lou W. Kim
Abstract
Protein phosphatase 2A (PP2A) regulatory B56 subunits play multifaceted and context- dependent roles in
cancer progression by modulating key signaling pathways that govern cell growth, survival, migration, and
apoptosis. Dysregulation of PP2A-B56 complexes is commonly observed across diverse malignancies,
contributing to oncogenic signaling, therapy resistance, and tumor development. Recent advances have
uncovered complex mechanisms controlling PP2A-B56 function, including post-translational modifications
such as nitration and phosphorylation, protein interactions, and viral exploitation, highlighting the nuanced
role of these subunits in tumor biology. The development of isoform-specific modulators and innovative
biosensors offers promising avenues for precise therapeutic targeting of PP2A-B56 dysfunction in cancer.
Continued investigation into the regulatory networks and context-specific functions of PP2A-B56 is critical
for unlocking new strategies to combat tumor progression and overcome treatment resistance.
Full Text: PDF |
DOI: https://doi.org/10.30845/ijast.v14p7
Article History:
Received: 11 August 2025 | Accepted: 2 October
2025 | Published: 4 October 2025
Reviewer(s):
Dr. Limor Rimer, Department of Obstetrics and Gynecology, Maccabi Health Services, Israel. ORCID iD:
https://orcid.org/0000-0001-5027-5115.
Email: [email protected]
Address for Correspondence:
Lou W. Kim, Department of Biological Sciences, College of Arts, Sciences, and
Education, +Biochemistry PhD program, Florida International University,
Miami, Florida, USA 33199.
Email: [email protected]
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