Cerebral Disorders of Preterm Infants from Women with Autoimmune Disorders of Pregnancy
Huseynova S.A., Bagirova H.F., Hasanov S.Sh., Mukhtarova S.N., Alasgarova S.M.

Abstract
Introduction. The objective of study was to determine the severity of central nervous system (CNS) injury and main perinatal outcome of infants born to women with antiphospholipid syndrome. Material and methods. 100 women with abnormal pregnancy and intrauterine chronic hypoxia were examined. In 30 of the women positive level of anticardiolipin antibodies (ACA) was found. 70 preterm babies from mothers with negative titer of anticardiolipin antibodies, but exposured to intrauterine hypoxia were investigated as control study. Brain tissue damage was estimated on the base of neurospesific enolase (NSE) and glial fibrillary acid protein (GFAP) levels in umbilical cord blood (UCB) and in the peripheral blood during early neonatal period. Level of both neurospesific proteins were detected by immunenzyme assay. Results. NSE level was higher in very low birth weight (VLBW) infants of both subgroups. GFAP level in UCB of all infants from ACA positive mothers was higher and more significantly difference (p<0.05) detected between VLBW babies from ACA positive women and control babies. To the end of early neonatal period GFAP of VLBW newborns of this group was statisically increased till 66,8±3,2. But NSE level stayed as high as in the first hours of life. Conclusion. High level of GFAP till the end of neonatal period of these babies confirms continuing of ischemic process and severe perinatal ensephalopathy.

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