Synthesis, Characterization and Antioxidant Activity of Some 4-Amino-5-Phenyl-4h-1, 2, 4-Triazole-3-Thiol Derivatives
Ayah Abdul Hameed, Firas Hassan

Abstract
A series of triazole derivative were synthesized by cyclization reaction, the benzoic acid hydrazide ( 1) was synthesized by reaction of methyl benzoate with hydrazine hydrate then compound (1) was reacted with CS2 in solution of alkali ethanol to give potassium dithiocarbazinate salt (2) , the basic nucleus 4-amino-5-phenyl-1-4H-1,2,4-triazole -3-thiol 3 was prepared by cyclization of potassium salt (2) with hydrazine hydrate using water as solvent under reflux condition . compound (3) was subjected to addition reaction with different aldehydes to synthesize Schiff bases (4a,b) which were cyclized by treating with thioglycolic acid to prepare compounds( 5a,b) .all the synthesized compound were confirmed by their melting point ,FTIR ,U.V-visible ,1HNMR spectra, , micro elemental analysis and evaluated for their antioxidant activity by using stable free radical 1,1-diphenyl-2-picryl-hydrazyl DPPH .Of all tested compounds , compound (5b) was the most active in all concentrations compared to standard Ascorbic acid with an IC50 value 5.84 μg/ml .

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