International Journal of Applied Science and Technology

ISSN 2221-0997 (Print), 2221-1004 (Online) 10.30845/ijast

Synthesis, Characterization, Biological Activities and Antioxidant Study of Gabapentin Derivatives and Their Complexes with [Cu(II), Zn(II]
Dhafir M. Husain Al-Mudhaffar, Ali H. Al-Mowali, Usama H. Al-Badran

Synthesis of some gabapentin derivatives derived from condensation of one mole of selected acid chlorides with one mole of Gabapentin in basic medium have been carried out. These derivatives which act as ligands, were characterized by FT-IR, CHN, 1HNMR,13CNMR and mass spectra measurements. Complexes of gabapentin derivatives were prepared by adding MCl2, where M = Cu(II) and Zn(II), to gabapentin derivatives (L1, L2, L3, L4 and L5), in 1:2 molal ratio. The complexes (L6 � L13) have been characterized by FT-IR, 1HNMR, ,13CNMR and CHN elemental analysis. The biological activities of the ligands and their complexes showed appreciable antibacterial activities against two types of bacteria, E.coli and staphylococcus aureus. Antioxidant properties of some derivatives and complexes showed excellent properties and others gave lower antioxidant properties.

Full Text: PDF